/* The Blueprint look: a technical drawing of a drug discovery campaign.
 * BUILD_SPEC sections 6.2 to 6.4. Sheets themselves are in sheets.css. */

*,
*::before,
*::after { box-sizing: border-box; }

html { -webkit-text-size-adjust: 100%; }

body {
  margin: 0;
  padding: 0;
  min-height: 100vh;
  background-color: var(--bg);
  /* The grid lives on the app ground only. Prose and tables sit on --surface so text
   * never fights the grid. Two sizes: a fine 8px grid and a heavier 80px rule. */
  background-image:
    linear-gradient(to right, var(--grid) 1px, transparent 1px),
    linear-gradient(to bottom, var(--grid) 1px, transparent 1px),
    linear-gradient(to right, var(--grid) 1px, transparent 1px),
    linear-gradient(to bottom, var(--grid) 1px, transparent 1px);
  background-size: 80px 80px, 80px 80px, 16px 16px, 16px 16px;
  color: var(--ink);
  font-family: var(--ui);
  font-size: 15px;
  line-height: 1.5;
}

/* Every numeral, residue id, PDB code and assay value is mono with tabular figures,
 * so columns of numbers line up and a changing value does not shift its neighbours. */
.mono,
code,
kbd,
th.num,
td.num,
.value,
.residue,
.pdb-id,
.title-block {
  font-family: var(--mono);
  font-variant-numeric: tabular-nums;
  font-feature-settings: "tnum" 1;
}

.prose {
  font-family: var(--prose);
  font-size: 1.12rem;
  line-height: 1.62;
}

h1, h2, h3, h4 {
  font-family: var(--ui);
  font-weight: 600;
  letter-spacing: 0.01em;
  margin: 0 0 calc(var(--unit) * 1.5);
}

h1 { font-size: 1.35rem; }
h2 { font-size: 1.1rem; text-transform: uppercase; letter-spacing: 0.08em; }
h3 { font-size: 0.95rem; color: var(--ink-dim); }

a { color: var(--target); text-decoration-thickness: 1px; text-underline-offset: 2px; }
a:hover { text-decoration-thickness: 2px; }

/* Focus is always visible: this app is meant to be driven from the keyboard. */
:focus-visible {
  outline: 2px solid var(--focus);
  outline-offset: 2px;
}

button,
select,
input {
  font: inherit;
  color: var(--ink);
  background: var(--surface-2);
  border: var(--rule) solid var(--line);
  border-radius: var(--radius);
  padding: 4px 10px;
  cursor: pointer;
}

button:hover,
select:hover { border-color: var(--line-strong); }

button[aria-pressed="true"],
button.is-active {
  border-color: var(--target);
  color: var(--target);
}

/* ---------------------------------------------------------------- drawing grammar
 * Implemented once, used by every panel. Colour carries meaning, so the eye reads a
 * target/anti-target pair without a legend. */

.measure-line {
  stroke: var(--measure);
  stroke-width: 1.5;
  fill: none;
}

.measure-label {
  fill: var(--measure);
  font-family: var(--mono);
  font-size: 11px;
}

.annotation-line {
  stroke: var(--target);
  stroke-width: 1.25;
  stroke-dasharray: 3 2;      /* 3-2 dash, per the drawing grammar */
  fill: none;
}

.annotation-label {
  fill: var(--ink);
  font-family: var(--ui);
  font-size: 12px;
}

.anti .annotation-line,
.anti-overlay .annotation-line { stroke: var(--anti); }
.anti .annotation-label,
.anti-overlay .annotation-label { fill: var(--anti); }

.clash-line {
  stroke: var(--loss);
  stroke-width: 2;
  fill: none;
}

.gain { color: var(--gain); }
.loss { color: var(--loss); }
.delta-gain::before { content: "▲ "; color: var(--gain); }
.delta-loss::before { content: "▼ "; color: var(--loss); }

/* Motif colours: the same residue role reads the same in 3D, on the ruler and in a chip. */
.motif-gatekeeper { --motif: var(--measure); }
.motif-hinge { --motif: var(--target); }
.motif-DFG { --motif: #C792EA; }
.motif-catalytic_lys { --motif: #7FDBCA; }
.motif-glycine_rich_loop { --motif: #9BB8D3; }
.motif-P_loop { --motif: #9BB8D3; }
.motif-switch_I { --motif: #7FDBCA; }
.motif-switch_II { --motif: #C792EA; }
.motif-solvent_front { --motif: #8FB4CF; }
.motif-front_pocket { --motif: #6FD3FF; }
.motif-back_pocket { --motif: #FFB4A2; }
.motif-mutation_site { --motif: var(--anti); }
.motif-other { --motif: var(--ink-dim); }

/* ------------------------------------------------------------------------- motion
 * Measure lines draw themselves in 240 ms on selection. Everything else is instant. */

@keyframes draw-measure {
  from { stroke-dashoffset: var(--dash-length, 100); }
  to { stroke-dashoffset: 0; }
}

.measure-line.is-drawing {
  stroke-dasharray: var(--dash-length, 100);
  animation: draw-measure 240ms ease-out forwards;
}

.morph { transition: opacity 240ms ease-out, transform 240ms ease-out; }

@media (prefers-reduced-motion: reduce) {
  .measure-line.is-drawing,
  .morph,
  * {
    animation-duration: 0.01ms !important;
    animation-iteration-count: 1 !important;
    transition-duration: 0.01ms !important;
    scroll-behavior: auto !important;
  }
}

/* Depictions are rendered once and shown on both themes: gc chem rewrites carbon and bond
 * black to currentColor, so the ink token colours them here. */
/* A depiction is drawn at 320x240 and scales to its container, but it must never grow
 * taller than the panel holding it: the selected-compound sheet was overflowing. */
.depiction { display: grid; place-items: center; }

.depiction svg {
  color: var(--ink);
  width: 100%;
  max-width: 320px;
  height: auto;
  max-height: 240px;
}

.visually-hidden {
  position: absolute;
  width: 1px;
  height: 1px;
  margin: -1px;
  padding: 0;
  overflow: hidden;
  clip-path: inset(50%);
  white-space: nowrap;
}